This web page was produced as an assignment for Genetics 564, an undergraduate course at UW-Madison .
What is protein homology?
Protein homology describes the degree of similarity of two proteins in two different organisms due to common ancestry. Proteins are classified as homologous if they are highly similar to each other.
Identifying homologs
Gene homologs can be identified using BLAST, a bioinformatics tool that aligns and compares an input sequence (DNA, mRNA or protein) to similar sequences in its database. BLAST can be used to provide information on how conserved a sequence is as compared to that in another organism.
DRD2 protein homologs
Protein homology describes the degree of similarity of two proteins in two different organisms due to common ancestry. Proteins are classified as homologous if they are highly similar to each other.
Identifying homologs
Gene homologs can be identified using BLAST, a bioinformatics tool that aligns and compares an input sequence (DNA, mRNA or protein) to similar sequences in its database. BLAST can be used to provide information on how conserved a sequence is as compared to that in another organism.
DRD2 protein homologs
Organism | Protein Name | Accession Number | GI Number | Amino Acid Sequence | % Identical |
Human (Homo sapiens) | D(2) dopamine receptor isoform long [Homo sapiens] | NP_000786.1 | 4503385 | FASTA | |
Chimpanzee (Pan troglodytes) | D(2) Dopamine receptor [Pan troglodytes] | NP_001029100.1 | 76677939 | FASTA | 100% |
Rhesus Macaque (Macaca mulatta) | PREDICTED: D(2) dopamine receptor isoform 3 [Macaca mulatta] | XP_001085571.1 | 109108710 | FASTA | 99% |
Horse (Equus caballus) | PREDICTED: D(2) dopamine receptor isoform X3 [Equus caballus] | XP_005611631.1 | 545221210 | FASTA | 98% | Pig (Sus scrofa) | PREDICTED: Equus caballus dopamine receptor D2 (DRD2), transcript variant X3, mRNA | NP_001231182.1 | 346716328 | FASTA | 97% |
Rabbit (Oryctolagus cuniculus) | PREDICTED: D(2) dopamine receptor isoform X2 [Oryctolagus cuniculus] | NM_010077.2 | 148747211 | FASTA | 90% |
Orang Utan (Pongo abelii) | PREDICTED: D(2) dopamine receptor isoform X1 [Pongo abelii] | XP_009245349.1 | 686738621 | FASTA | 96% |
House Mouse (Mus musculus) | D(2) dopamine receptor [Mus musculus] | NM_001113290.1 | 148747212 | FASTA | 95% |
Chicken (Gallus gallus) | D(2) dopamine receptor [Gallus gallus] | NP_001106761.1 | 164518970 | FASTA | 81% | Blind cave fish (Astyanax mexicanus) | PREDICTED: D(2)-like dopamine receptor-like isoform X1 [Astyanax mexicanus] | XP_007245302.1 | 597762680 | FASTA | 69% |
Discussion
DRD2 is found to be fairly conserved in vertebrates but not invertebrates.
DRD2 is found to be fairly conserved in vertebrates but not invertebrates.